The estrogen on/off switch

This article is dealing at the cellular level but I thought some of you might be interested in it.  It is continuing on the path of giving patients more personalized treatments. Why take tamoxifen if it will not work for you right?

Source: Vince Dollard
Emory University

A tiny modification called methylation on estrogen receptors prolongs the life of these growth-driving molecules in breast cancer cells, according to research by scientists at Emory University’s Winship Cancer Institute.   The results are published in the May 9, 2008 issue of the journal Molecular Cell.

Most breast cancers contain estrogen receptors, which enable them to grow in the presence of the hormone estrogen. Their presence can determine whether tumors will respond to the estrogen-blocking drug tamoxifen.

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